Events / Vision Seminar: Silvia Finnemann

Vision Seminar: Silvia Finnemann

April 8, 2024
12:00 PM - 1:15 PM

102AB Richards Labs, 3710 Hamilton Walk, Philadelphia, PA 19104

Silvia Finnemann
Bepler Chair in Biology
Department of Biological Sciences
Fordham University


Photoreceptor outer renewal: molecular mechanisms and link to retinal disease


Routine diurnal photoreceptor outer segment renewal is a fundamental homeostatic process in the vertebrate retina. The talk will focus on molecules and pathways that mediate cross-talk between photoreceptors and neighboring retinal pigment epithelial (RPE) cells to ensure timely exposure of the “eat me” signal phosphatidylserine at outer segment tips followed by their prompt engulfment. Additionally, I will discuss our recent work suggesting that RPE intrinsic anti-inflammatory signaling relies on RPE phagocytic receptors to protect the neural retina from distress and degeneration.